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Rapid screen for UTI
Works on the basis that certain bacteria reduce nitrate to nitrite
Detects about 70% of Clinically significant UTI bacteria
All bacteria don't posses the enzyme reductase necessary to break nitrate down (most gram - do and most gram + don't)
First morning specimen is best
Requires 100,000 organisms per mL to get a positive
Positive is any degree of uniform pink color
Urine has to be in the bladder with the bacteria approximately 4 hrs to convert bitrate to nitrite
Useful in detecting cystitis, pyelonephritis, monitoring antibiotic therapy and as a screening test
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