Disease/ DisorderDefinitionSomatic Symptom Disorder (SSD) is a new diagnosis listed in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM) released in 2013. SSD loosely replaces several old diagnoses, namely Somatization Disorder, Undifferentiated Somatoform Disorder, Pain Disorder, and also includes a portion of the old diagnosis Hypochondriasis. Show
The diagnostic criteria changed in such a way as to simplify and re-conceptualize the criteria to be easier for non-psychiatrists to diagnose.1 The focus has shifted towards positive diagnostic signs and symptoms, rather than on the absence of a medical explanation for the signs and symptoms. The new positive diagnostic criteria focus on symptoms that significantly impact the individual for an extended time period. The diagnosis of SSD under the DSM-V is considered controversial due to the concern that it is overly inclusive and creates a large potential for false positives; however, it is a slightly more restrictive diagnosis than the previous DSM-IV criteria which allowed for many patients with “medically unexplained” symptoms to be diagnosed with somatoform disorder. 2 Somatic Symptom Disorder Diagnostic Criteria per DSM V1Criterion A: One or more somatic symptoms that are distressing or result in significant disruption of daily life. Criterion B: Excessive thoughts, feelings, or behaviors related to the somatic symptoms or associated health concerns as manifested by at least one of the following:
Criterion C: Although any one somatic symptom may not be continuously present, the state of being symptomatic is persistent (typically more than 6 months) Further, the DSM states that you should specify if the diagnosis is:1
And the DSM asks that you specify the current severity:1
EtiologyNo published research accounts for the etiology of SSD. Epidemiology including risk factors and primary preventionThe prevalence of SSD is difficult to establish as the new diagnostic criteria under the DSM-V subsumes other somatoform disorders such as hypochondriasis and panic disorder. Extrapolating data from the prior diagnoses that contribute to SSD would be theoretical at best as not all patients with the former diagnoses will qualify for the SSD diagnoses under the DSM-V, particularly in those with unexplained symptoms.2 Also, there are additional patients with explained medical conditions that can now be diagnosed with SSD if they suffer from the B and C criteria of SSD. There is some concern that these patients with known medical diseases will start to be labeled as mentally ill if they also now qualify for the SSD diagnosis.3,4 Despite all of this, some have still hypothesized from the previously published literature that the prevalence of SSD may be 4-6% of the general population, but as discussed, this is theoretical at best.1,5 Prevalence rates of SSD are suspected to be higher, up to 25 to 60%, in patients with functional somatic syndromes such as fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome.6 Risk factors/primary prevention:
Patho-anatomy/physiologyThere is not a known anatomical or physiological explanation for SSD. Because the DSM-V definition of SSD was established in 2013, most of the hypotheses regarding the pathogenesis of SSD is informed by studies on illness anxiety disorder and functional somatic syndromes such as fibromyalgia and irritable bowel disorder. Childhood experiences of parental neglect and sexual abuse may be associated with somatization.10,11 In 2017, the International Association for the Study of Pain (IASP) developed a new descriptor of pain distinct from nociceptive and neuropathic pain called nociplastic pain. They define nociplastic pain as “pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain.” This new descriptor was chosen as a response to the literature supporting decreased connectivity of the medial prefrontal cortex to the posterior constituents of the default mode network and increased connectivity to the insular cortex in patients with functional somatic syndromes. Some pain experts prefer the term centralized somatization, but that term was ultimately rejected by the IASP as they felt that not all forms of nociplastic pain are of purely central origin. Patients with SSD would be categorized under nociplastic or mixed pain, with many benign somatic sensations or physical symptoms becoming overly amplified by patients who have become overly sensitized to pain.12 High levels of health anxiety also contribute to the perpetuation or worsening of SSD as patients tend to vigilantly monitor their bodies for any symptoms or changes, which is why persistently high levels of anxiety about health have now been incorporated into the diagnostic criterion B of SSD.1 Some evidence supports a genetic component in the pathogenesis of SSD. A national study (n>28,000 individuals) found that genetic factors contribute anywhere between 7 to 21% to somatic symptoms with the remaining contribution likely attributable to environmental factors.13 There is also some evidence to suggest a genetic component in the co-occurrence of anxiety and depression with somatic symptoms.14 Disease progression including natural history, disease phases or stages, disease trajectory (clinical features and presentation over time)There is some evidence that suggests prodromal symptoms of SSD appear in childhood and adolescence.10 There is limited data published on the course of SSD, but one study suggests that in elderly individuals with SSD rated as severe, they display lower cognition as measured by the Mini Mental-State Examination.15 Another publication states that old data referring to somatoform disorders in general is applicable to SSD, suggesting that self-reports of bodily weakness is a predictor of symptom severity.16 Multiple studies have associated high somatic symptom burden to greater health care utilization and functional impairment, independent of age, anxiety disorders, depressive disorders, and general medical disorders. Based on the data that is available regarding the course of illness in somatization disorders, the course is thought to be chronic, with waxing and waning of symptoms. There is no clear evidence regarding the rate of recovery or recurrence of SSD.17 Specific secondary or associated conditions and complicationsAssociated conditions include:
No complications have been clearly established for SSD. However, one paper that focused on the somatic symptom burden reports that patients with a high somatic symptom burden were more likely to score high on self-reported measures of health care utilization as well as have high scores on measures of psychological distress..21 However, they note that their criteria for somatic symptom burden differs from the DSM-V criteria for SSD, and that while the connection to SSD is noteworthy, it is premature to draw definitive conclusions about SSD utilizing their data. Other diagnoses to consider when suspecting SSD include mental health disorders such as depression, panic disorder, generalized anxiety disorder, substance use disorder, and chronic fatigue syndrome which may present with some similar symptoms.17 Essentials of AssessmentHistoryHistory and interview are essential to diagnose SSD, and patients should fulfill all three diagnostic criteria as mentioned above. Somatic symptoms that are common in SSD include:1,22
The most common somatic symptoms in children and adolescents with SSD include abdominal pain, nausea, back pain, blurry vision, fatigue, and headache.23 It is important to differentiate SSD from Illness anxiety disorder which is also a new diagnosis under the DSM-V where a patient has no or only very mild symptoms, but has great anxiety and preoccupation that they have a serious disease. Another disorder that it is important to distinguish from SSD is generalized anxiety disorder which could be confused with the B criteria, but it is not due solely to somatic symptoms. Rather, it is anxiety due to multiple events, situations, or activities.1 Physical examinationThere is no physical examination component that is necessary for the diagnosis of SSD. Under the new DSM-V criteria, there is no need to rule out medical causes of the symptoms because they can have the diagnosis of SSD whether or not their symptoms can be medically explained.1 However, a thorough physical exam can be helpful to 1) rule out serious underlying medical issue, 2) ease patient’s anxieties and assure patients that their complaints are taken seriously, and 3) establish a baseline to detect changes over time. It should also be noted that as new symptoms develop, they cannot be merely lumped into a prior SSD diagnosis, but need to be evaluated like any other new symptoms, including a physical exam. Functional assessmentThere may be a tendency amongst SSD patients to avoid physical activity. There is one study that states that patients with high somatic symptom burden have increased functional impairment as measured by the Sheehan Disability Scale, although they note that their study doesn’t match directly with DSM-V criteria of SSD, but is somewhat similar.21 Laboratory studiesThere is no laboratory study to confirm the diagnosis of SSD, as it is not necessary to rule out medical causes of symptoms to have the diagnosis of SSD under DSM-V. Due diligence and concern should be given to all new presenting symptoms in a patient regardless of their diagnosis of SSD. However, excessive diagnostic testing in the setting of low clinical suspicion in a patient with SSD can be detrimental as it could lead to false positive results, which exacerbate health anxiety and/or could lead to unnecessary treatments/procedures.24 ImagingThere are no imaging studies that confirm the diagnosis of SSD. There is, however, research stating that there are brain regions associated with a greater vulnerability to pain and catastrophization of symptoms including the dorsolateral prefrontal, insular, rostral anterior cingulate, and premotor and parietal cortices.25 However, imaging to assess for irregularities of these areas is neither inclusive nor exclusive of the diagnosis, and no research has shown any correlation with SSD in particular. Supplemental assessment toolsSeveral questionnaires have been developed and can be helpful in the assessment of SSD.
The combination of the SSD-12 with either the PHQ-15 or the SS-8 considerably improves identification of people at risk for somatic symptom disorder.29 Early predictions of outcomesData from nine population-based studies (n = 28,377) using various instruments (PHQ-15, Zerssen 14, Lifetime Composite International Diagnostic Interview [Lifetime CIDI], Symptom Checklist-90-Revised [SCL-90-R], and Somatic Symptom Inventory Score [SSI score]) found that higher scores were significantly correlated with health status and healthcare use, even after adjustment for confounders such as age, gender, anxiety/depression, and general medical illness.22 However, as the diagnosis of SSD was established in 2013, there are limited publications evaluating outcomes of SSD and none on early predictors of outcomes. EnvironmentalIt is unclear if environmental influences impact the development, progression, or treatment of SSD. However, the DSM-V reapplies research pre-dating the DSM-V, which suggests that SSD is more frequent in patients with low socioeconomic status, few years of education, and those who have recently experience stressful life events.1 Social role and social support systemThere is no published data regarding the assessment of SSD specifically in regards to social role or support system. However, organic illnesses, stressful working conditions, and adverse life events have been identified as precipitating factors for bodily distress which may play a role in the development of SSD.1,30 Rehabilitation Management and TreatmentsAvailable or current treatment guidelinesThere are no guidelines regarding the treatment of SSD. Much of the evidence regarding pharmacotherapy, cognitive behavior therapy, and mindfulness-based therapy for somatic symptom disorder is based on research that pre-dates the existence of the SSD diagnosis as it stands in DSM-V. With that being said, in 2018, a clinical neuroscience journal published recommendations on the management of SSD based on the best available evidence and clinical expertise. Those recommendations include but are not limited to the following practice principles:31
There is some limited research published specifically on treatment of SSD based on the new DSM-V diagnostic criteria. A two-patient case study found that Blonanserin, an atypical antipsychotic that is not FDA approved, was useful in treating SSD when given with SSRIs.33 Rehabilitation guidelinesThere are no treatment guidelines when it comes to the physical rehabilitation of patients with SSD. However, developing a close collaboration between the patient and the mental health practitioner would likely be useful in coping with the B criteria. And it is important to note that SSD patients tend to engage in less physical activity and score higher on disability rating systems, thus an explicitly set goal of functional improvement rather than complete resolution of somatic symptom(s) is crucial.17,31 Coordination of careEarly recognition of SSD and involving psychology/psychiatry to help manage symptoms is important. It may also be important to educate ancillary staff such as nursing and physical, occupational, and speech therapists regarding SSD. Patient & family educationKey patient educational issues include: Family education should include: Translation into practice: practice “pearls”/performance improvement in practice (PIPs)/changes in clinical practice behaviors and skillsEarly suspicion and involvement of psychology/psychiatry for evaluation and treatment can be helpful in diagnosing and treating comorbidities such as anxiety and depression as well as sexual trauma. Psychologists and psychiatrists can also help to reinforce focus on improved function rather than resolution of somatic symptoms.17 Establishing a collaborative, therapeutic alliance with the patient by acknowledging and legitimizing somatic symptoms is essential. This requires a delicate balance between adequately assessing for serious medical issues and limiting diagnostic testing and referrals to specialists when there is a low pretest probability of serious disease.24,31 Cutting Edge/ Emerging and Unique Concepts and PracticeThe entire diagnosis is still considered cutting edge as patients transition from previous DSM-IV diagnoses to DSM-V diagnoses such as SSD. While there is limited research addressing treatment., blonanserin, an atypical antipsychotic, is a cutting edge treatment that has been shown to be effective but has not yet received FDA approval.33 The 2017 IASP inclusion of nociplastic pain is also a new and unique concept that may contribute to a better understanding of and management of SSD in the future.12 Gaps in the Evidence- Based KnowledgeSSD is a new DSM-V diagnosis, therefore there is a large gap of evidence-based knowledge. As mentioned, a gap exists for evidence regarding etiology, epidemiology, pathophysiology, assessment, pharmacological and other forms of treatment, and impact on physical rehabilitation. There is also a need for research regarding specific populations like adolescents and how SSD affects them functionally.34 Since the publication of the DSM-V, there has been some criticism that it either over- or under-diagnoses some patients. There have been some publications that attempt to break down SSD into subgroups based on certain characteristics in order to aid in defining treatment goals and choosing treatment options for patients with SSD. Further research on this topic is warranted.35 References
Original Version of the TopicJason Hunt, MD, Ankit Patel, MD. Somatic Symptom Disorder. 9/21/2016 Author DisclosureShawn Uraine, MD Sarah H Yoon, MD How do you assess somatic symptom disorder?To determine a diagnosis, you'll likely have a physical exam and any tests your doctor recommends. Your doctor or other health care provider can help determine if you have any health conditions that need treatment.
What is the most common symptom reported with somatic symptom disorder?Pain is the most common symptom, but whatever your symptoms, you have excessive thoughts, feelings or behaviors related to those symptoms, which cause significant problems, make it difficult to function and sometimes can be disabling.
What are examples of somatic disorders?They include somatization disorder, undifferentiated somatoform disorder, hypochondriasis, conversion disorder, pain disorder, body dysmorphic disorder, and somatoform disorder not otherwise specified. These disorders often cause significant emotional distress for patients and are a challenge to family physicians.
In which mental health disorder are physical or psychological symptoms or both fabricated to assume the sick role?Munchausen's syndrome is a psychological disorder where someone pretends to be ill or deliberately produces symptoms of illness in themselves. Their main intention is to assume the "sick role" so that people care for them and they are the centre of attention.
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