Which of the following nursing interventions should be taken for a client who complains of nausea and vomits one hour after taking his glyburide DiaBeta )?

General

Inhaltsverzeichnis Show

• Indications
• Pharmacokinetics
• Contraindication/Precautions
• Adverse Reactions/Side Effects
• Interactions
• Route/Dosage
• Availability (generic available)
• Potential Diagnoses
• Implementation
• Patient/Family Teaching
• Evaluation/Desired Outcomes
• Which of the following nursing interventions should be taken for a client who complains of nausea and vomits one hour after taking his glyburide?
• Which of the following methods of insulin administration would be used in the initial treatment of hyperglycemia in a client with diabetic ketoacidosis?
• Which one of the following methods techniques will the nurse use when giving insulin to a thin person?
• When a client is in diabetic ketoacidosis the insulin that would be administered immediately is?

High Alert Medication: This medication bears a heightened risk of causing significant patient harm when it is used in error.

**BEERS Drug**

Genetic Implications:

Pronunciation:
glye-byoo-ride

Trade Name(s)

• DiaBeta
• Euglucon 
• Glynase

Ther. Class.

antidiabetics

Pharm. Class.

sulfonylureas

Indications

PO Control of blood sugar in type 2 diabetes mellitus when diet therapy fails. Requires some pancreatic function.

Action

• Lowers blood sugar by stimulating the release of insulin from the pancreas and increasing the sensitivity to insulin at receptor sites.
• May also decrease hepatic glucose production.

Therapeutic Effect(s):

Lowering of blood sugar in diabetic patients.

Pharmacokinetics

Absorption: Well absorbed following oral administration; micronized forms have better absorption.

Distribution: Reaches high concentrations in bile and crosses the placenta.

Metabolism and Excretion: Mostly metabolized by the liver (primarily by CYP2C9).

Half-life: 10 hr.

TIME/ACTION PROFILE (hypoglycemic activity)

Contraindication/Precautions

Contraindicated in:

• Hypersensitivity
• Hypersensitivity to sulfonamides (cross-sensitivity may occur)
• Type 1 diabetes
• Diabetic coma or ketoacidosis
• Concurrent use of bosentan
•  Lactation:  Lactation.

Use Cautiously in:

• Severe cardiovascular or hepatic disease
•  Glucose 6-phosphate dehydrogenase deficiency (↑ risk of hemolytic anemia);
• Severe renal impairment (↑ risk of hypoglycemia)
• Infection, stress, or changes in diet may alter requirements for control of blood sugar
• Impaired thyroid, pituitary, or adrenal function
• Malnutrition, high fever, prolonged nausea, or vomiting
• OB:  Safety not established during pregnancy; insulin recommended during pregnancy
• Pedi:   Safety and effectiveness not established in children
• Geri:  ↑ sensitivity; dose ↓ may be required.

Adverse Reactions/Side Effects

Derm: ERYTHEMA MULTIFORME, photosensitivity, exfoliative dermatitis, rash

Endo: hypoglycemia

F and E: hyponatremia

GI: constipation, cramps, diarrhea, drug-induced hepatitis, dyspepsia, ↑ appetite, nausea, vomiting

Hemat: APLASTIC ANEMIA, agranulocytosis, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia

Metabolic: ↑ weight

Neuro: dizziness, drowsiness, headache, weakness

* CAPITALS indicate life-threatening.
Underline indicate most frequent.

Interactions

Drug-Drug

• ↑ risk of elevated liver enzymes when used with  bosentan  (avoid concurrent use).
• Ingestion of  alcohol  may result in disulfiram-like reaction.
• Effectiveness may be ↓ by concurrent use of  diuretics, corticosteroids,  phenothiazines, oral contraceptives,  estrogens,  thyroid preparations,  phenytoin,   nicotinic acid,  sympathomimetics,  rifampin, and  isoniazid.
•  Alcohol,  androgens (testosterone),  chloramphenicol,  ACE inhibitors,  disopyramide,  fluoxetine,  clarithromycin,  fluoroquinolones, MAO inhibitors,  NSAIDs  (except diclofenac),  salicylates ,  sulfonamides, and  warfarin  may ↑ the risk of hypoglycemia.
• Concurrent use with  warfarin  may alter the response to both agents (↑ effects of both initially, then ↓ activity); close monitoring recommended during any changes in dose.
•  Beta-adrenergic blockers  may mask the signs and symptoms of hypoglycemia.
• May ↑ cyclosporine  levels.
•  Colesevelam  may ↓ effects; administer glyburide ≥4 hr before colesevelam
•  Topiramate  may ↓ levels and ↓ effects

Route/Dosage

The non-micronized formulation (Diabeta) cannot be used interchangeably with the micronized formulation (Glynase PresTab)

PO (Adults): DiaBeta (non-micronized)– 2.5–5 mg once daily initially (range 1.25–20 mg/day).  Glynase PresTab (micronized)– 1.5–3 mg/day initially (range 0.75–12 mg/day; doses >6 mg/day should be given as divided doses). Increments should not exceed 1.5 mg/wk.

PO Geriatric Patients: DiaBeta (non-micronized)– 1.25–2.5 mg/day initially; may be ↑ by 2.5 mg/day weekly.   Glynase PresTab (micronized)– 0.75–3 mg/day; may be ↑ by 1.5 mg/day weekly.

Availability (generic available)

Tablets: 1.25 mg, 2.5 mg, 5 mg

Micronized tablets: 1.5 mg, 3 mg, 6 mg

In Combination with: metformin (Glucovance); see combination drugs.

Assessment

• Observe for signs and symptoms of hypoglycemic reactions (sweating, hunger, weakness, dizziness, tremor, tachycardia, anxiety). Patients on concurrent beta-blocker therapy may have very subtle signs and symptoms of hypoglycemia.
• Assess patient for allergy to sulfonamides.

Lab Test Considerations:

Monitor serum glucose and glycosylated hemoglobin (HbA1C ) periodically during therapy to evaluate effectiveness.

• Monitor CBC periodically during therapy. Report ↓ in blood counts promptly.
• May cause an ↑ in AST, LDH, BUN, and serum creatinine.

Toxicity and Overdose:

Overdose is manifested by symptoms of hypoglycemia. Mild hypoglycemia may be treated with administration of oral glucose. Severe hypoglycemia should be treated with IV D50W followed by continuous IV infusion of more dilute dextrose solution at a rate sufficient to keep serum glucose at approximately 100 mg/dL.

Potential Diagnoses

• Imbalanced nutrition: more than body requirements (Indications) 
• Noncompliance (Patient/Family/Teaching) 

Implementation

• High Alert: Accidental administration of oral hypoglycemic agents to non-diabetic adults and children has resulted in serious harm or death.
• High Alert: Do not confuse glyburide with glipizide.

• Patients stabilized on a diabetic regimen who are exposed to stress, fever, trauma, infection, or surgery may require administration of insulin.

  • To convert from other oral hypoglycemic agents, gradual conversion is not required. For insulin dose of less than 20 units/day, change to glyburide can be made without gradual dose adjustment. Patients taking 20 or more units/day should convert gradually by receiving glyburide and a 25–30% reduction in insulin dose every day or every 2nd day with gradual insulin dose reduction as tolerated. Monitor serum or glucose and ketones at least 3 times/day during conversion.
• PO May be administered once in the morning or divided into 2 doses. Administer with meals to ensure best diabetic control and to minimize gastric irritation. Do not administer after last meal of the day.
  • Nonmicronized glyburide  should not be taken with a meal high in fat.  Micronized glyburide  cannot be substituted for  nonmicronized glyburide  Preparations are not equivalent.

Patient/Family Teaching

• Instruct patient to take medication at same time each day. Take missed doses as soon as remembered unless almost time for next dose. Do not take if unable to eat.
• Explain to patient that this medication controls hyperglycemia but does not cure diabetes. Therapy is long term.
• Review signs of hypoglycemia and hyperglycemia with patient. If hypoglycemia occurs, advise patient to drink a glass of orange juice or ingest 2–3 tsp of sugar, honey, or corn syrup dissolved in water or an appropriate number of glucose tablets and notify health care professional.
• Concurrent use of alcohol may cause a disulfiram-like reaction (abdominal cramps, nausea, flushing, headaches, and hypoglycemia).
• Encourage patient to follow prescribed diet, medication, and exercise regimen to prevent hypoglycemic or hyperglycemic episodes.
• Instruct patient in proper testing of serum glucose and ketones. Monitor closely during periods of stress or illness and health care professional notified if significant changes occur.
• May occasionally cause dizziness or drowsiness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
• Caution patient to avoid other medications, especially aspirin and alcohol, while on this therapy without consulting health care professional.
• Caution patient to use sunscreen and protective clothing to prevent photosensitivity reactions.
• Advise patient to inform health care professional of medication regimen prior to treatment or surgery.
• Advise patient to notify health care professional promptly if unusual weight gain, swelling of ankles, drowsiness, shortness of breath, muscle cramps, weakness, sore throat, rash, or unusual bleeding or bruising occurs.
• Rep:  Insulin is the recommended method of controlling blood sugar during pregnancy. Counsel female patients to use a form of contraception other than oral contraceptives and to notify health care professional promptly if pregnancy is planned or suspected or if breastfeeding.
• Advise patient to carry a form of sugar (sugar packets, candy) and identification describing disease process and medication regimen at all times.
• Emphasize the importance of routine follow-up exams.

Evaluation/Desired Outcomes

Control of blood glucose levels without the appearance of hypoglycemic or hyperglycemic episodes.